L-甲狀腺素鈉-蘇州東南藥業股份有限公司

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聯系人: 賈經理；胡總

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地址: 江蘇省蘇州市工業園區仁愛路150號C316室

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Chinese Name 中文名	L-甲狀腺素鈉
English Name 英文名	Levothyroxine Sodium
Alias 別名	3,5,3’,5’-tetraiodothyronine;beta-[(3,5-diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl]alanine;l-3,5,3’,5’-tetraiodothyronine;l-t4;o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosin;o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine;t4(hormone);tetraiodothyronine
CAS NO.	25416-65-3
Formula 分子式	C15H10I4NO4
M.W. 分子量	798.85
Class 分類	原料藥

L-Thyroxine is a synthetic form of thyroxine and a hormone replacement drug. L-Thyroxine is typically used to treat hypothyroidism. L-Thyroxine may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing.由兩個3，5-二碘酪氨酸分子偶聯而成的一種碘化的酪氨酸衍生物，是甲狀腺的主要激素。主要控制耗氧速率和總代謝速率。具有促進一般組織代謝，提高神經興奮性和身體發育作用。用以治療甲狀腺機能減退，粘液性水腫和克汀病等。左甲狀腺素鈉（L-T4)作用遲緩而持久，起效較慢，病人易耐受。1次/d，服用方便，且劑量易于掌握。左甲狀腺素鈉（L-T4)在外周組織脫碘，產生足量的碘塞羅寧(T3)滿足生理需要，是治療甲減的理想制劑，現已成為治療甲減的首選藥物。而且左甲狀腺素鈉（L-T4)的半衰期長達7天，吸收相對緩慢，即使漏服1天也無多大影響，可以于漏服的次日加服1天的劑量。該藥物常見的商品名包括：歐洲的：Thyrax, Euthyrox（中文名：優甲樂）, Levaxin, L-thyroxine, Eltroxin 和 Thyrax Duotab；北美的：Thyrox in South Asia; Eutirox, Tirosint,Levoxyl and Synthroid；中國大陸的：“澤寧”“尤仙”等。同時，還有一些無商品名產品。

化學數據

溶解性 (25°C)

?DMSO 155 mg/mL

?水 <1 mg/mL

?乙醇 <1 mg/mL

穩定性 2年 -20°C粉狀

2周4°C溶于DMSO

6月-80°C溶于DMSO

【熔點】

207 °C

【比旋光度】

16 o (c=2,1M HCl/alcohol 1/4)

【儲存條件】

Store at 0-5°C

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2. Svensson J, Ericsson UB, Nilsson P, et al.. Levothyroxine treatment reduces thyroid size in children and adolescents with chronic autoimmune thyroiditis. The Journal of clinical endocrinology and metabolism. 2006.May, 91 (5): 1729–34. doi:10.1210/jc.2005-2400.PMID 16507633.
3. Dietlein, M; Wegscheider, K; Vaupel, R; Schmidt, M; Schicha, H. Management of multinodular goiter in Germany (Papillon 2005): do the approaches of thyroid specialists and primary care practitioners differ?. Nuklearmedizin. Nuclear medicine. 2007, 46 (3): 65–75.PMID 17549317.
4. Frilling, A; Liu, C; Weber, F. Benign multinodular goiter. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society. 2004, 93 (4): 278–81. PMID 15658668.
5. Synthroid (Levothyroxine Sodium) Drug Information: Uses, Side Effects, Drug Interactions and Warnings. RxList. [2010-07-18].
6. Irizarry, Lisandro. Toxicity, Thyroid Hormone. WebMd. 2010-04-23 [2010-10-31].
7. Ruth H. Michel, Patricia J. Neafsey, Laura Cox Dzurec: Self Medication Practices among Patients taking Levothyroxine. The Internet Journal of Advanced Nursing Practice. 2004. Volume 6 Number 2
8. Lilja JJ, Laitinen K, Neuvonen PJ. Effects of grapefruit juice on the absorption of levothyroxine. Br J Clin Pharmacol. 2005.September, 60 (3): 337–41. doi:10.1111/j.1365-2125.2005.02433.x. PMC 1884777. PMID 16120075.
9. Benvenga, Salvatore; Bartolone, L.; Pappalardo, M.A.; Russo, A.; Lapa, D.; Giorgianni, G.; Saraceno, G.; Trimarchi, F. Altered Intestinal Absorption of L-Thyroxine Caused by Coffee. Thyroid (New York: Mary Ann Liebert, Inc.). March 2008, 18 (3): 293–301 [2009-05-16].doi:10.1089/thy.2007.0222. PMID 18341376

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